NAD and NADP cofactor biosynthesis global (with 298 genomes present)

Variants List

Variant Organism Pathway
Index Status All(298) E(16) B(261) A(21) B3 -> NADP N-Ribosylnicotinamide -> NADP Trp -> NADP IndAm -> NADP Asp -> NADP
Basic form functional 61 0 58 3 complete complete
Variant 1 functional 39 1 38 0 complete
Variant 2 functional 38 0 38 0 complete
Variant 3 functional 23 0 23 0 complete complete complete
Variant 4 non-functional 16 1 14 1
Variant 5 functional 11 0 11 0 complete
Variant 6 functional 10 0 10 0 complete complete
Variant 7 functional 6 0 1 5 complete
Variant 8 functional 6 0 2 4 complete
Variant 9 functional 5 0 5 0 complete
Variant 10 functional 5 0 5 0 complete
Variant 11 functional 5 1 4 0 complete complete
Variant 12 functional 5 0 0 5 complete
Variant 13 functional 4 1 3 0 complete
Variant 14 functional 4 0 4 0 complete complete complete
Variant 15 functional 3 0 3 0 complete complete
Variant 16 non-functional 3 0 3 0
Variant 17 functional 3 0 3 0 complete complete
Variant 18 functional 3 0 3 0 complete complete complete
Variant 19 functional 3 0 0 3 complete
Variant 20 functional 3 0 3 0 complete
Variant 21 functional 3 2 1 0 complete
Variant 22 functional 2 0 2 0 complete
Variant 23 functional 2 2 0 0 complete complete complete
Variant 24 functional 2 0 2 0 complete
Variant 25 functional 2 0 2 0 complete
Variant 26 functional 2 1 1 0 complete
Variant 27 functional 2 0 2 0 complete complete
Variant 28 non-functional 2 0 2 0
Variant 29 functional 2 0 2 0 complete complete
Variant 30 functional 2 2 0 0 complete
Variant 31 functional 2 2 0 0 complete
Variant 32 functional 2 0 2 0 complete
Variant 33 functional 1 0 1 0 complete
Variant 34 functional 1 0 1 0 complete complete
Variant 35 functional 1 0 1 0 complete
Variant 36 functional 1 1 0 0 complete complete
Variant 37 functional 1 0 1 0 complete
Variant 38 functional 1 0 1 0 complete
Variant 39 functional 1 0 1 0 complete
Variant 40 functional 1 0 1 0 complete
Variant 41 functional 1 0 1 0 complete complete
Variant 42 functional 1 0 1 0 complete
Variant 43 functional 1 1 0 0 complete complete complete
Variant 44 functional 1 0 1 0 complete
Variant 45 functional 1 0 1 0 complete complete
Variant 46 functional 1 0 1 0 complete
Variant 47 functional 1 0 1 0 complete complete
Variant 48 functional 1 1 0 0 complete
Variant 49 functional 1 0 1 0 complete

Subsystem Diagram


Functional Roles

IDAbbrevFunctional role
1TDOTryptophan 2
2IDOIndoleamine 2
3KFA_eKynurenine formamidase (EC 3.5.1.9)
4KFA_bKynurenine formamidase
5KMOKynurenine 3-monooxygenase (EC 1.14.13.9)
6KYNKynureninase (EC 3.7.1.3)
7HAD3-hydroxyanthranilate 3
8ASPOXL-aspartate oxidase (EC 1.4.3.16)
9ASPDHAspartate dehydrogenase [same functional role as] (EC 1.4.3.16)
10QSYNQuinolinate synthetase (EC 4.1.99.-)
11QAPRTQuinolinate phosphoribosyltransferase [decarboxylating] (EC 2.4.2.19)
12NAMNATNicotinate-nucleotide adenylyltransferase (EC 2.7.7.18)
13NMNATNicotinamide-nucleotide adenylyltransferase (EC 2.7.7.1)
14NADSNAD synthetase (EC 6.3.1.5)
15GATGlutamine amidotransferase chain of NAD synthetase
16NADKNAD kinase (EC 2.7.1.23)
17NAMNicotinamidase (EC 3.5.1.19)
18NAPRTNicotinate phosphoribosyltransferase (EC 2.4.2.11)
19NMPRTNicotinamide phosphoribosyltransferase (EC 2.4.2.12)
20PNUCRibosyl nicotinamide transporter
21RNK_bRibosylnicotinamide kinase (EC 2.7.1.22)
22RNK_eRibosylnicotinamide kinase

Committed Intermediates

IDAbbrevDescription
1TrpTryptophan
2IndAmIndoleamine
3I-QN-formylkynurenine
4II-QKynurenine
5III-Q3-hydroxykynurenine
6IV-Q3-hydroxyanthranilate
7V-Qalpha-amino-beta-carboxymuconic semialdehyde
8QuinolinateQuinolinate
9AspAspartate
10VIII-QIminoaspartate
11IX-QDihydroxyacetone phosphate
12IL-Aspartate
13IIIminoaspartate
14IIIDihydroxyacetone phosphate
15QuinolinateQuinolinate
16B3Nicotinamide
17VNicotinic acid
18PRPP5-Phosphoribosyl 1-pyrophosphate
19VINaMN (Nicotinate mononucleotide)
20VIINMN (Nicotinamide mononucleotide)
21VIIIN-Ribosylnicotinamide
22IXDeamido-NAD
23NADNicotinamide adenine dinucleotide
24NADPNAD phosphate