Coenzyme A Biosynthesis (with 264 genomes annotated)

Variants List

Variant Organism Pathway
Index Status All(263) E(11) B(239) A(13) B5 -> CoA L-Aspartate + 3-Methyl-2-oxobutanoate -> CoA
Basic form functional 116 1 115 0 complete complete
Variant 1 functional 48 7 40 1 complete
Variant 2 functional 48 3 45 0 complete
Variant 3 non-functional 22 0 22 0
Variant 4 non-functional 8 0 8 0
Variant 5 functional 6 0 0 6 complete
Variant 6 functional 6 0 4 2 complete
Variant 7 non-functional 4 0 0 4
Variant 8 functional 2 0 2 0 complete
Variant 9 non-functional 2 0 2 0
Variant 10 functional 1 0 1 0 complete

Subsystem Diagram


Functional Roles

IDAbbrevFunctional role
1PANFPantothenate:Na+ symporter (TC 2.A.21.1.1)
2PBALPantoate--beta-alanine ligase (EC 6.3.2.1)
3ASPDCAspartate 1-decarboxylase (EC 4.1.1.11)
4KPHMT3-methyl-2-oxobutanoate hydroxymethyltransferase (EC 2.1.2.11)
5KPRED2-dehydropantoate 2-reductase (EC 1.1.1.169)
6KAREDKetol-acid reductoisomerase (EC 1.1.1.86)
7PANKPantothenate kinase /Pantothenate kinase (EC 2.7.1.33) / Type II/Pantothenate kinase (EC 2.7.1.33) / Type III(EC 2.7.1.33)
8PANK2Pantothenate kinase /Pantothenate kinase (EC 2.7.1.33) / Type II/Pantothenate kinase (EC 2.7.1.33) / Type III(EC 2.7.1.33)
9PANK3Pantothenate kinase /Pantothenate kinase (EC 2.7.1.33) / Type II/Pantothenate kinase (EC 2.7.1.33) / Type III(EC 2.7.1.33)
10PPCSPhosphopantothenoylcysteine synthetase (EC 6.3.2.5)
11PPCDCPhosphopantothenoylcysteine decarboxylase (EC 4.1.1.36)
12PPATPhosphopantetheine adenylyltransferase /Phosphopantetheine adenylyltransferase (EC 2.7.7.3) / Dephospho-CoA kinase (EC 2.7.1.24)(EC 2.7.7.3)
13PPAT2Phosphopantetheine adenylyltransferase /Phosphopantetheine adenylyltransferase (EC 2.7.7.3) / Dephospho-CoA kinase (EC 2.7.1.24)(EC 2.7.7.3)
14DPCKDephospho-CoA kinase /Phosphopantetheine adenylyltransferase (EC 2.7.7.3) / Dephospho-CoA kinase (EC 2.7.1.24)(EC 2.7.1.24)

Committed Intermediates

IDAbbrevDescription
1IL-Aspartate
2IIbeta-Alanine
3III3-Methyl-2-oxobutanoate
4IV2-Dehydropantoate
5V(R)-Pantoate
6B5Vitamin B5
7VID-4'-Phosphopantothenate
8VIIL-Cysteine
9VIII(R)-4'-Phosphopantothenoyl-L-cysteine
10IXPantetheine 4'-phosphate
11XDephospho-CoA
12CoACoenzyme A