The unique domain connections

Common domain combinations in all organisms

Connection	Domain1	Domain2	Effect	genomes	view graph
1	ATP-synt_ab	ATP-synt_ab_C	2	53	graph
2	ATP-synt_ab	ATP-synt_ab_N	2	53	graph
3	ATP-synt_ab_C	ATP-synt_ab_N	2	53	graph
4	CPSase_L_D2	CPSase_L_chain	2	45	graph
5	helicase_C	DEAD	2	53	graph
6	Hydrolase	E1-E2_ATPase	2	49	graph
7	EFG_C	EFG_IV	2	53	graph
8	EFG_C	GTP_EFTU	2	53	graph
9	EFG_C	GTP_EFTU_D2	2	53	graph
10	GTP_EFTU	EFG_IV	2	53	graph
11	EFG_IV	GTP_EFTU_D2	2	53	graph
12	enolase	enolase_N	100000	51	graph
13	GATase_2	SIS	2	45	graph
14	GatB	GatB_N	2	47	graph
15	gpdh	gpdh_C	2	51	graph
16	GTP_EFTU	GTP_EFTU_D2	2	53	graph
17	GTP_EFTU	GTP_EFTU_D3	2	52	graph
18	GTP_EFTU_D2	GTP_EFTU_D3	2	52	graph
19	tRNA-synt_2b	HGTP_anticodon	2	53	graph
20	KH	Ribosomal_S3_C	2	51	graph
21	ldh_C	ldh	100000	45	graph
22	PGM_PMM	PGM_PMM_I	2	49	graph
23	PGM_PMM	PGM_PMM_II	2	49	graph
24	PGM_PMM	PGM_PMM_III	2	48	graph
25	PGM_PMM_II	PGM_PMM_I	2	52	graph
26	PGM_PMM_I	PGM_PMM_III	2	50	graph
27	PGM_PMM_II	PGM_PMM_III	2	50	graph
28	pyr_redox	pyr_redox_dim	2	49	graph
29	ribonuc_red_lgC	ribonuc_red_lg	2	47	graph
30	Ribosomal_L11	Ribosomal_L11_N	100000	51	graph
31	Ribosomal_L2	Ribosomal_L2_C	100000	53	graph
32	Ribosomal_L5	Ribosomal_L5_C	100000	53	graph
33	Ribosomal_S5	Ribosomal_S5_C	100000	52	graph
34	RNA_pol_Rpb1_1	RNA_pol_Rpb1_2	2	51	graph
35	RNA_pol_Rpb1_1	RNA_pol_Rpb1_3	2	51	graph
36	RNA_pol_Rpb1_1	RNA_pol_Rpb1_4	2	50	graph
37	RNA_pol_Rpb1_1	RNA_pol_Rpb1_5	2	49	graph
38	RNA_pol_Rpb1_2	RNA_pol_Rpb1_3	2	51	graph
39	RNA_pol_Rpb1_2	RNA_pol_Rpb1_4	2	50	graph
40	RNA_pol_Rpb1_2	RNA_pol_Rpb1_5	2	50	graph
41	RNA_pol_Rpb1_3	RNA_pol_Rpb1_4	2	51	graph
42	RNA_pol_Rpb1_3	RNA_pol_Rpb1_5	2	51	graph
43	RNA_pol_Rpb1_4	RNA_pol_Rpb1_5	2	51	graph
44	RNA_pol_Rpb2_6	RNA_pol_Rpb2_7	2	52	graph
45	RNase_PH	RNase_PH_C	2	48	graph
46	SRP54	SRP54_N	2	52	graph
47	SRP54	SRP_SPB	2	52	graph
48	SRP_SPB	SRP54_N	2	51	graph
49	Topoisom_bac	Toprim	2	51	graph
50	tRNA_anti	tRNA-synt_2	2	50	graph

Unique(missing) domain connections in the three kindoms

cf: the frequency of the connection in the genomes; d1: the frequency of component domain 1 in the genomes; d2: the frequency of component domain 2 in the genomes; gn: the number of sampled genomes in each kindom; the specific connections of common domains are highlighted in green cells, while the specific connections of a common domain with other domains are highlighted in yellow cells.

Connection	Domain1	Domain2	Effect	Archaea				Bacteria				Eukaryote
Connection	Domain1	Domain2	Effect	cf	f1	f2	gn	cf	f1	f2	gn	cf	f1	f2	gn
# Unique connections in Archaea
1	DEAD	HHH	2	13	16	16	16	0	30	27	30	0	7	7	7
2	DUF650	DUF651	100000	14	14	14	16	0	0	0	30	0	0	0	7
3	GAD	GatB	2	13	14	14	16	0	25	27	30	0	2	6	7
4	GAD	GatB_N	2	14	14	15	16	0	25	27	30	0	2	6	7
5	GAD	GatB_Yqey	2	13	14	13	16	0	25	28	30	0	2	5	7
6	helicase_C	HHH	2	13	16	16	16	1	30	27	30	0	7	7	7
7	PyrI	PyrI_C	100000	14	14	14	16	4	5	4	30	0	0	0	7
# Unique connections in Bacteria
1	5_3_exonuc_N	5_3_exonuclease	2	0	0	2	16	30	30	30	30	1	1	4	7
2	DNA_pol_A	5_3_exonuc_N	2	0	0	0	16	27	27	30	30	0	7	1	7
3	DNA_pol_A	5_3_exonuclease	2	0	0	2	16	27	27	30	30	0	7	4	7
4	B3_4	FDX-ACB	2	0	11	1	16	25	28	25	30	0	7	6	7
5	B3_4	tRNA_bind	2	0	11	16	16	28	28	30	30	0	7	7	7
6	FDX-ACB	B5	2	0	1	15	16	25	25	30	30	0	6	7	7
7	tRNA_bind	B5	2	0	16	15	16	28	30	30	30	0	7	7	7
8	BRCT	DNA_ligase_N	2	0	0	0	16	30	30	30	30	0	7	0	7
9	BRCT	DNA_ligase_OB	2	0	0	0	16	30	30	30	30	0	7	0	7
10	BRCT	DNA_ligase_ZBD	2	0	0	0	16	25	30	25	30	0	7	0	7
11	CBS	CorC_HlyC	2	2	16	2	16	26	30	26	30	1	7	1	7
12	DUF21	CorC_HlyC	2	2	3	2	16	25	28	26	30	1	6	1	7
13	DEAD	TRCF	2	0	16	0	16	27	30	27	30	0	7	0	7
14	DNA_ligase_OB	DNA_ligase_N	2	0	0	0	16	30	30	30	30	0	0	0	7
15	DNA_ligase_N	DNA_ligase_ZBD	2	0	0	0	16	25	30	25	30	0	0	0	7
16	DNA_ligase_OB	DNA_ligase_ZBD	2	0	0	0	16	25	30	25	30	0	0	0	7
17	DNA_pol3_beta	DNA_pol3_beta_2	2	0	0	0	16	26	29	27	30	0	0	0	7
18	DNA_pol3_beta	DNA_pol3_beta_3	2	0	0	0	16	29	29	30	30	0	0	0	7
19	DNA_pol3_beta_3	DNA_pol3_beta_2	2	0	0	0	16	27	30	27	30	0	0	0	7
20	DnaB	DnaB_C	100000	0	0	1	16	29	29	30	30	0	0	1	7
21	FDX-ACB	tRNA_bind	2	0	1	16	16	25	25	30	30	0	6	7	7
22	Glyco_tran_28_C	Glyco_transf_28	100000	3	4	3	16	27	27	27	30	1	7	2	7
23	GreA_GreB	GreA_GreB_N	100000	0	0	0	16	27	27	29	30	0	0	0	7
24	helicase_C	TRCF	2	0	16	0	16	27	30	27	30	0	7	0	7
25	KH	Ribosomal_S3_N	2	0	16	0	16	28	30	30	30	0	7	0	7
26	S1	KH	2	1	16	16	16	27	30	30	30	1	7	7	7
27	KOW	NusG	100000	2	16	2	16	28	30	30	30	0	7	0	7
28	Transpeptidase	PBP_dimer	2	0	0	0	16	26	27	26	30	0	0	0	7
29	Phe_tRNA-synt_N	tRNA-synt_2d	100000	0	0	15	16	25	25	30	30	0	0	7	7
30	S4	PseudoU_synth_2	100000	0	16	0	16	30	30	30	30	1	7	7	7
31	Ribosomal_L9_C	Ribosomal_L9_N	100000	0	0	0	16	29	29	30	30	1	1	5	7
32	Ribosomal_S3_C	Ribosomal_S3_N	2	0	16	0	16	30	30	30	30	0	7	0	7
33	RNA_pol_A_bac	RNA_pol_A_CTD	100000	0	14	0	16	30	30	30	30	0	7	0	7
34	sigma70_r1_2	sigma70_r2	2	0	0	1	16	27	27	30	30	1	1	1	7
35	sigma70_r1_2	sigma70_r3	2	0	0	0	16	27	27	29	30	1	1	1	7
36	sigma70_r1_2	sigma70_r4	2	0	0	0	16	26	27	28	30	1	1	1	7
37	sigma70_r3	sigma70_r2	2	0	0	1	16	29	29	30	30	1	1	1	7
38	sigma70_r4	sigma70_r2	2	0	0	1	16	28	28	30	30	1	1	1	7
39	sigma70_r3	sigma70_r4	2	0	0	0	16	27	29	28	30	1	1	1	7
40	Toprim	zf-CHC2	100000	0	16	0	16	29	30	29	30	0	7	0	7
# Unique connections in Eukaryote
1	PGAM	6PF2K	100000	0	7	0	16	0	25	0	30	7	7	7	7
2	AAA	MIT	3	2	16	2	16	0	30	0	30	6	7	7	7
3	ACOX	Acyl-CoA_dh	2	0	0	8	16	0	0	14	30	7	7	7	7
4	Alpha_adaptinC2	Adaptin_N	2	0	0	1	16	0	0	0	30	7	7	7	7
5	GARS	AIRS	2	0	15	15	16	0	21	21	30	6	7	7	7
6	AIRS	GARS_B	2	0	15	14	16	0	21	21	30	6	7	7	7
7	AIRS	GARS_C	2	0	15	15	16	0	21	21	30	6	7	7	7
8	AIRS	GARS_N	2	0	15	15	16	0	21	21	30	6	7	7	7
9	GARS	AIRS_C	2	0	15	15	16	0	21	21	30	6	7	7	7
10	AIRS_C	GARS_B	2	0	15	14	16	0	21	21	30	6	7	7	7
11	AIRS_C	GARS_C	2	0	15	15	16	0	21	21	30	6	7	7	7
12	GARS_N	AIRS_C	2	0	15	15	16	0	21	21	30	6	7	7	7
13	AlaDh_PNT_C	Saccharop_dh	2	0	0	3	16	0	17	8	30	6	7	7	7
14	AlaDh_PNT_N	Saccharop_dh	2	0	0	3	16	0	17	8	30	6	7	7	7
15	Ald_Xan_dh_C	CO_deh_flav_C	2	0	4	3	16	0	11	8	30	6	6	6	7
16	Ald_Xan_dh_C	FAD_binding_5	2	0	4	3	16	0	11	10	30	6	6	6	7
17	Ald_Xan_dh_C	fer2	2	0	4	13	16	0	11	22	30	6	6	7	7
18	Ald_Xan_dh_C	fer2_2	2	0	4	3	16	0	11	11	30	6	6	6	7
19	Ald_Xan_dh_C2	CO_deh_flav_C	2	0	4	3	16	0	11	8	30	6	6	6	7
20	Ald_Xan_dh_C2	FAD_binding_5	2	0	4	3	16	0	11	10	30	6	6	6	7
21	Ald_Xan_dh_C2	fer2	2	0	4	13	16	0	11	22	30	6	6	7	7
22	Ald_Xan_dh_C2	fer2_2	2	0	4	3	16	0	11	11	30	6	6	6	7
23	SWIRM	Amino_oxidase	100000	0	0	11	16	0	0	15	30	6	7	7	7
24	ANF_receptor	lig_chan	2	0	6	0	16	0	10	0	30	6	6	6	7
25	ank	ArfGap	2	0	4	0	16	0	15	0	30	6	7	7	7
26	ank	BTB	2	0	4	0	16	0	15	0	30	7	7	7	7
27	ank	ion_trans	2	0	4	7	16	0	15	7	30	6	7	7	7
28	ank	PH	2	0	4	0	16	0	15	0	30	7	7	7	7
29	ank	pkinase	2	0	4	9	16	0	15	18	30	6	7	7	7
30	ank	TIG	2	0	4	1	16	0	15	4	30	7	7	7	7
31	ank	zf-DHHC	3	0	4	0	16	0	15	0	30	7	7	7	7
32	TPR	APC8	100000	0	13	0	16	0	25	0	30	6	7	6	7
33	ArfGap	PH	2	0	0	0	16	0	0	0	30	6	7	7	7
34	jmjC	ARID	2	0	0	0	16	0	0	0	30	6	7	7	7
35	ARID	jmjN	2	0	0	0	16	0	0	0	30	6	7	7	7
36	PHD	ARID	2	0	0	0	16	0	0	0	30	6	7	7	7
37	Armadillo_seg	IBB	100000	0	0	0	16	0	0	0	30	7	7	7	7
38	arrestin	arrestin_C	100000	0	0	0	16	0	0	0	30	6	6	6	7
39	bromodomain	BAH	2	0	0	0	16	0	0	0	30	6	7	7	7
40	BAH	GATA	2	0	0	0	16	0	0	0	30	6	7	7	7
41	BAH	myb_DNA-binding	2	0	0	1	16	0	0	1	30	6	7	7	7
42	PHD	BAH	2	0	0	0	16	0	0	0	30	7	7	7	7
43	SH3	BAR	2	0	0	0	16	0	0	0	30	6	7	6	7
44	WD40	Beach	2	0	2	0	16	0	5	0	30	6	7	7	7
45	Biotin_carb_C	Carboxyl_trans	2	0	7	7	16	3	24	25	30	6	7	7	7
46	biotin_lipoyl	Carboxyl_trans	2	0	14	7	16	3	28	25	30	7	7	7	7
47	BRCT	IMS	100000	0	0	5	16	0	30	18	30	6	7	7	7
48	BRCT	NIF	2	0	0	0	16	0	30	1	30	7	7	7	7
49	bromodomain	helicase_C	2	0	0	16	16	0	0	30	30	6	7	7	7
50	bromodomain	SNF2_N	2	0	0	9	16	0	0	17	30	6	7	7	7
51	BTB	MATH	2	0	0	0	16	0	0	0	30	6	7	7	7
52	DAG_PE-bind	C2	2	0	0	0	16	0	0	0	30	6	7	7	7
53	C2	PI-PLC-X	2	0	0	0	16	0	0	0	30	7	7	7	7
54	C2	PI-PLC-Y	2	0	0	0	16	0	0	0	30	7	7	7	7
55	pkinase	C2	2	0	9	0	16	0	18	0	30	6	7	7	7
56	C2	pkinase_C	2	0	0	0	16	0	0	0	30	6	7	7	7
57	C2	RasGAP	2	0	0	0	16	0	0	0	30	6	7	6	7
58	Peptidase_C2	Calpain_III	2	0	0	0	16	0	0	0	30	6	6	6	7
59	CPSase_L_chain	Carboxyl_trans	2	0	13	7	16	3	25	25	30	7	7	7	7
60	CPSase_L_D2	Carboxyl_trans	2	0	13	7	16	3	25	25	30	7	7	7	7
61	IBN_NT	CAS_CSE1	100000	0	0	0	16	0	0	0	30	6	7	6	7
62	CH	EB1	5	0	0	0	16	0	0	0	30	7	7	7	7
63	IQ	CH	2	0	0	0	16	0	1	0	30	6	7	7	7
64	chromo	helicase_C	2	0	0	16	16	0	0	30	30	7	7	7	7
65	PHD	chromo	2	0	0	0	16	0	0	0	30	6	7	7	7
66	chromo	SNF2_N	2	0	0	9	16	0	0	17	30	7	7	7	7
67	Clathrin	Clathrin_propel	100000	0	0	0	16	0	0	0	30	7	7	7	7
68	PH	CNH	2	0	0	0	16	0	0	0	30	6	7	7	7
69	ion_trans	cNMP_binding	2	0	7	1	16	0	7	24	30	6	7	7	7
70	Patatin	cNMP_binding	2	0	0	1	16	2	18	24	30	6	7	7	7
71	cNMP_binding	RIIa	2	0	1	0	16	0	24	0	30	6	7	6	7
72	CO_deh_flav_C	fer2	2	0	3	13	16	5	8	22	30	6	6	7	7
73	CO_deh_flav_C	fer2_2	2	0	3	3	16	5	8	11	30	6	6	6	7
74	WD40	Coatomer_WDAD	100000	0	2	0	16	0	5	0	30	7	7	7	7
75	CPSase_L_chain	CPSase_sm_chain	2	0	13	13	16	0	25	20	30	6	7	7	7
76	CPSase_L_chain	GATase	2	0	13	15	16	0	25	28	30	6	7	7	7
77	CPSase_L_D2	CPSase_sm_chain	2	0	13	13	16	0	25	20	30	6	7	7	7
78	CPSase_L_D2	GATase	2	0	13	15	16	0	25	28	30	6	7	7	7
79	CPSase_sm_chain	CPSase_L_D3	2	0	13	13	16	0	20	19	30	6	7	6	7
80	CPSase_L_D3	GATase	2	0	13	15	16	0	19	28	30	6	6	7	7
81	CPSase_sm_chain	MGS	2	0	13	8	16	0	20	22	30	6	7	7	7
82	CRAL_TRIO	CRAL_TRIO_N	2	0	0	0	16	0	0	0	30	7	7	7	7
83	SGS	CS	2	0	0	0	16	0	0	0	30	7	7	7	7
84	CwfJ_N_1	CwfJ_N_2	2	0	0	0	16	0	0	0	30	7	7	7	7
85	cyclin	cyclin_C	2	0	0	0	16	0	0	0	30	7	7	7	7
86	pkinase	DAG_PE-bind	2	0	9	0	16	0	18	0	30	6	7	7	7
87	DAG_PE-bind	pkinase_C	2	0	0	0	16	0	0	0	30	6	7	7	7
88	DAGKc	DAGKa	2	0	1	0	16	0	13	0	30	6	7	6	7
89	Metallophos	DBR1	100000	0	16	0	16	0	29	0	30	6	7	6	7
90	NUDIX	DCP2	100000	0	16	0	16	0	26	0	30	6	7	6	7
91	dDENN	DENN	2	0	0	0	16	0	0	0	30	6	6	6	7
92	dDENN	uDENN	2	0	0	0	16	0	0	0	30	6	6	6	7
93	PHD	DDT	2	0	0	0	16	0	0	0	30	6	7	7	7
94	DEAD	Sec63	2	1	16	1	16	0	30	0	30	7	7	7	7
95	DEAD	zf-CCHC	2	0	16	0	16	0	30	0	30	6	7	7	7
96	DENN	uDENN	2	0	0	0	16	0	0	0	30	6	6	6	7
97	RGS	DEP	2	0	0	0	16	0	0	1	30	6	6	7	7
98	DNA_topoisoIV	DNA_gyraseB	2	0	6	6	16	0	30	30	30	7	7	7	7
99	HATPase_c	DNA_topoisoIV	2	0	16	6	16	0	30	30	30	7	7	7	7
100	DnaJ	myb_DNA-binding	2	0	6	1	16	0	30	1	30	6	7	7	7
101	DnaJ	Sec63	3	0	6	1	16	0	30	0	30	7	7	7	7
102	TPR	DnaJ	2	0	13	6	16	2	25	30	30	6	7	7	7
103	DPPIV_N_term	Peptidase_S9	100000	0	0	10	16	2	2	14	30	7	7	7	7
104	dsrm	DUF283	2	0	1	0	16	0	29	0	30	6	7	6	7
105	helicase_C	dsrm	2	0	16	1	16	0	30	29	30	6	7	7	7
106	dsrm	PAZ	2	0	1	0	16	0	29	0	30	6	7	6	7
107	DUF283	PAZ	2	0	0	0	16	0	0	0	30	6	6	6	7
108	DUF283	Ribonuclease_3	2	0	0	0	16	0	0	29	30	6	6	7	7
109	DUF382	PSP	2	0	0	0	16	0	0	0	30	7	7	7	7
110	DUF383	DUF384	100000	0	0	0	16	0	0	0	30	6	6	7	7
111	dynamin	dynamin_2	2	0	0	0	16	0	0	0	30	7	7	7	7
112	dynamin	GED	2	0	0	0	16	0	0	0	30	7	7	7	7
113	PH	dynamin	2	0	0	0	16	0	0	0	30	6	7	7	7
114	dynamin_2	GED	2	0	0	0	16	0	0	0	30	7	7	7	7
115	PH	dynamin_2	2	0	0	0	16	0	0	0	30	6	7	7	7
116	EF1G_domain	GST_C	2	0	0	1	16	0	0	13	30	7	7	7	7
117	EF1G_domain	GST_N	2	0	0	0	16	0	0	10	30	6	7	7	7
118	efhand	Ferric_reduct	2	0	1	0	16	0	7	0	30	6	7	7	7
119	ion_trans	efhand	2	0	7	1	16	0	7	7	30	6	7	7	7
120	efhand	mito_carr	4	0	1	0	16	0	7	0	30	7	7	7	7
121	eIF5_eIF2B	W2	100000	0	16	0	16	0	0	0	30	7	7	7	7
122	myb_DNA-binding	ELM2	2	0	1	0	16	0	1	0	30	6	7	6	7
123	ENTH	I_LWEQ	5	0	0	0	16	0	0	0	30	6	7	6	7
124	UIM	ENTH	5	0	0	0	16	0	0	0	30	6	7	7	7
125	thiored	Evr1_Alr	3	0	11	0	16	0	28	0	30	6	7	7	7
126	EXS	SPX	100000	0	0	0	16	0	0	0	30	6	7	7	7
127	LRR	F-box	2	0	2	0	16	1	6	1	30	7	7	7	7
128	WD40	F-box	2	0	2	0	16	0	5	1	30	7	7	7	7
129	heme_1	FA_desaturase	3	0	3	0	16	0	1	8	30	6	7	7	7
130	FAD_binding_1	flavodoxin	2	0	0	9	16	5	8	19	30	7	7	7	7
131	FAD_binding_5	fer2	2	2	3	13	16	5	10	22	30	6	6	7	7
132	FAD_binding_5	fer2_2	2	2	3	3	16	5	10	11	30	6	6	6	7
133	FAT	FATC	2	0	0	0	16	0	0	0	30	7	7	7	7
134	PI3_PI4_kinase	FAT	2	0	0	0	16	0	3	0	30	7	7	7	7
135	PI3_PI4_kinase	FATC	2	0	0	0	16	0	3	0	30	7	7	7	7
136	SH3	FCH	2	0	0	0	16	0	0	0	30	6	7	6	7
137	WW	FF	2	0	0	0	16	0	0	1	30	7	7	7	7
138	pkinase	FHA	2	0	9	3	16	0	18	11	30	6	7	7	7
139	TPR	FKBP	2	0	13	12	16	0	25	22	30	6	7	7	7
140	FYVE	PIP5K	2	0	0	0	16	0	0	0	30	6	7	7	7
141	G-patch	rrm	2	0	0	0	16	0	0	4	30	6	7	7	7
142	VHS	GAT	2	0	0	0	16	0	0	0	30	7	7	7	7
143	myb_DNA-binding	GATA	2	0	1	0	16	0	1	0	30	6	7	7	7
144	GATase	MGS	2	0	15	8	16	0	28	22	30	6	7	7	7
145	PH	GED	2	0	0	0	16	0	0	0	30	6	7	7	7
146	Gelsolin	Sec23_helical	2	0	0	0	16	0	0	0	30	7	7	7	7
147	Gelsolin	Sec23_trunk	2	0	0	0	16	0	0	0	30	7	7	7	7
148	Gelsolin	zf-Sec23_Sec24	2	0	0	0	16	0	0	0	30	7	7	7	7
149	Glyco_hydro_20	Glyco_hydro_20b	2	0	0	0	16	2	5	2	30	6	6	6	7
150	TBC	GRAM	2	0	0	0	16	0	0	0	30	6	7	7	7
151	HA2	S1	2	0	0	16	16	0	12	30	30	7	7	7	7
152	HECT	WW	2	0	0	0	16	0	0	0	30	6	7	7	7
153	helicase_C	myb_DNA-binding	2	0	16	1	16	0	30	1	30	6	7	7	7
154	PHD	helicase_C	2	0	0	16	16	0	0	30	30	6	7	7	7
155	helicase_C	S1	2	0	16	16	16	0	30	30	30	7	7	7	7
156	helicase_C	Sec63	2	1	16	1	16	0	30	0	30	7	7	7	7
157	zf-C3HC4	helicase_C	2	0	0	16	16	0	0	30	30	6	7	7	7
158	helicase_C	zf-CCHC	2	0	16	0	16	0	30	0	30	6	7	7	7
159	heme_1	Mo-co_dimer	2	0	3	0	16	0	1	4	30	6	7	6	7
160	heme_1	oxidored_molyb	2	0	3	9	16	0	1	11	30	6	7	6	7
161	W2	hexapep	2	0	0	15	16	0	0	25	30	7	7	7	7
162	hexokinase	hexokinase2	2	0	0	0	16	1	1	1	30	7	7	7	7
163	WHEP-TRS	HGTP_anticodon	2	0	0	16	16	0	0	30	30	6	6	7	7
164	pkinase	HR1	2	0	9	0	16	0	18	0	30	6	7	6	7
165	pkinase_C	HR1	2	0	0	0	16	0	0	0	30	6	7	6	7
166	Hydantoinase_A	Hydantoinase_B	100000	2	10	9	16	4	7	5	30	6	6	6	7
167	IQ	myosin_head	2	0	0	0	16	0	1	0	30	7	7	7	7
168	IQ	Myosin_N	2	0	0	0	16	0	1	0	30	7	7	7	7
169	jmjC	jmjN	2	0	0	0	16	0	0	0	30	7	7	7	7
170	PHD	jmjC	2	0	0	0	16	0	0	0	30	7	7	7	7
171	jmjC	zf-C5HC2	2	0	0	0	16	0	0	0	30	6	7	6	7
172	PHD	jmjN	2	0	0	0	16	0	0	0	30	6	7	7	7
173	pkinase	KA1	2	0	9	0	16	0	18	0	30	6	7	7	7
174	KOW	Ribosomal_L27e	2	0	16	0	16	0	30	0	30	6	7	6	7
175	KOW	Supt5	100000	0	16	0	16	0	30	0	30	7	7	7	7
176	ku	Ku_C	2	0	1	0	16	0	5	0	30	6	7	6	7
177	Ku_N	ku	2	0	0	1	16	0	0	5	30	7	7	7	7
178	myosin_head	M	2	0	0	6	16	0	0	2	30	6	7	7	7
179	MIF4G	MA3	2	0	0	0	16	0	0	0	30	7	7	7	7
180	MATH	UCH	2	0	0	0	16	0	0	0	30	7	7	7	7
181	Metallophos	Mre11_DNA_bind	100000	0	16	0	16	0	29	0	30	7	7	7	7
182	TPR	Metallophos	2	0	13	16	16	0	25	29	30	6	7	7	7
183	oxidored_molyb	Mo-co_dimer	2	0	9	0	16	4	11	4	30	6	6	6	7
184	mRNA_cap_C	mRNA_cap_enzyme	2	0	0	0	16	0	0	0	30	6	7	7	7
185	SNF2_N	myb_DNA-binding	2	0	9	1	16	0	17	1	30	6	7	7	7
186	SWIRM	myb_DNA-binding	2	0	0	1	16	0	0	1	30	6	7	7	7
187	ZZ	myb_DNA-binding	2	0	0	1	16	0	0	1	30	6	7	7	7
188	myosin_head	Myosin_N	2	0	0	0	16	0	0	0	30	7	7	7	7
189	SH3	myosin_head	2	0	0	0	16	0	0	0	30	6	7	7	7
190	NMT	NMT_C	100000	0	0	0	16	0	0	0	30	7	7	7	7
191	NOT	Not3	100000	0	0	0	16	0	0	0	30	6	7	6	7
192	rrm	NTF2	3	0	0	1	16	0	4	4	30	6	7	7	7
193	NTP_transf_2	PAP_assoc	2	0	16	0	16	0	14	0	30	7	7	7	7
194	PH	Oxysterol_BP	2	0	0	0	16	0	0	0	30	7	7	7	7
195	P	Peptidase_S8	100000	0	0	10	16	0	0	14	30	6	6	7	7
196	PA	TFR_dimer	2	0	5	0	16	0	6	0	30	6	7	6	7
197	rrm	PABP	2	0	0	0	16	0	4	0	30	7	7	7	7
198	PAP_central	PAP_RNA-bind	100000	0	0	0	16	0	0	0	30	7	7	7	7
199	PAZ	Piwi	100000	0	0	4	16	0	0	1	30	6	6	6	7
200	Ribonuclease_3	PAZ	2	0	0	0	16	0	29	0	30	6	7	6	7
201	pkinase	PB1	2	0	9	0	16	0	18	0	30	6	7	7	7
202	pkinase	PBD	2	0	9	0	16	0	18	0	30	6	7	7	7
203	Peptidase_M10	Peptidase_M10_N	2	0	0	0	16	0	0	0	30	6	6	6	7
204	Peptidase_M28	TFR_dimer	2	0	8	0	16	0	8	0	30	6	7	6	7
205	SH3	Peroxin-13_N	2	0	0	0	16	0	0	0	30	6	7	6	7
206	zf-C3HC4	Pex2_Pex12	2	0	0	0	16	0	0	0	30	6	7	7	7
207	pkinase	PH	2	0	9	0	16	0	18	0	30	6	7	7	7
208	PH	RhoGAP	2	0	0	0	16	0	0	0	30	7	7	7	7
209	SH3	PH	2	0	0	0	16	0	0	0	30	6	7	7	7
210	PH	START	2	0	0	0	16	0	0	1	30	6	7	6	7
211	PHD	SET	2	0	0	2	16	0	0	4	30	7	7	7	7
212	PHD	SNF2_N	2	0	0	9	16	0	0	17	30	6	7	7	7
213	PHD	zf-C5HC2	2	0	0	0	16	0	0	0	30	6	7	6	7
214	PI-PLC-X	PI-PLC-Y	2	0	0	0	16	0	0	0	30	7	7	7	7
215	PI3_PI4_kinase	PI3K_C2	2	0	0	0	16	0	3	0	30	7	7	7	7
216	PI3_PI4_kinase	PI3Ka	2	0	0	0	16	0	3	0	30	7	7	7	7
217	PI3K_C2	PI3Ka	2	0	0	0	16	0	0	0	30	7	7	7	7
218	pkinase	pkinase_C	2	0	9	0	16	0	18	0	30	7	7	7	7
219	pkinase	POLO_box	100000	0	9	0	16	0	18	0	30	6	7	6	7
220	pkinase	WD40	2	0	9	2	16	1	18	5	30	7	7	7	7
221	SET	Pre-SET	2	0	2	0	16	0	4	0	30	6	7	6	7
222	rrm	pro_isomerase	2	0	0	4	16	0	4	21	30	6	7	7	7
223	WD40	PWP2	100000	0	2	0	16	0	5	0	30	6	7	7	7
224	PX	PXA	2	0	0	0	16	0	0	0	30	7	7	7	7
225	R3H	zf-NF-X1	2	0	0	0	16	0	11	0	30	6	7	7	7
226	RasGEF	RasGEFN	2	0	0	0	16	0	0	0	30	6	6	6	7
227	RB_A	RB_B	100000	0	0	0	16	0	0	0	30	6	6	6	7
228	zf-CCHC	Retrotrans_gag	2	0	0	0	16	0	0	0	30	6	7	7	7
229	Ribosomal_L23	Ribosomal_L23eN	100000	0	16	0	16	0	30	0	30	7	7	7	7
230	ubiquitin	Ribosomal_L40e	100000	0	0	4	16	0	0	0	30	6	7	7	7
231	Rieske	UCR_TM	100000	0	8	0	16	0	19	0	30	6	7	7	7
232	RNA_pol_Rpb1_1	RNA_pol_Rpb1_6	2	0	15	0	16	0	29	0	30	7	7	7	7
233	RNA_pol_Rpb1_1	RNA_pol_Rpb1_7	2	0	15	0	16	0	29	0	30	7	7	7	7
234	RNA_pol_Rpb1_6	RNA_pol_Rpb1_2	2	0	0	15	16	0	0	29	30	7	7	7	7
235	RNA_pol_Rpb1_2	RNA_pol_Rpb1_7	2	0	15	0	16	0	29	0	30	7	7	7	7
236	RNA_pol_Rpb1_6	RNA_pol_Rpb1_3	2	0	0	15	16	0	0	29	30	7	7	7	7
237	RNA_pol_Rpb1_7	RNA_pol_Rpb1_3	2	0	0	15	16	0	0	29	30	7	7	7	7
238	RNA_pol_Rpb1_6	RNA_pol_Rpb1_4	2	0	0	15	16	0	0	29	30	7	7	7	7
239	RNA_pol_Rpb1_7	RNA_pol_Rpb1_4	2	0	0	15	16	0	0	29	30	7	7	7	7
240	RNA_pol_Rpb1_6	RNA_pol_Rpb1_7	2	0	0	0	16	0	0	0	30	7	7	7	7
241	RNA_pol_Rpb2_4	RNA_pol_Rpb2_2	2	3	15	5	16	0	0	3	30	7	7	7	7
242	RNA_pol_Rpb2_5	RNA_pol_Rpb2_2	2	3	15	5	16	0	0	3	30	7	7	7	7
243	RNA_pol_Rpb2_6	RNA_pol_Rpb2_2	2	3	15	5	16	3	30	3	30	7	7	7	7
244	RNA_pol_Rpb2_7	RNA_pol_Rpb2_2	2	3	15	5	16	3	30	3	30	7	7	7	7
245	RNA_pol_Rpb5_C	RNA_pol_Rpb5_N	100000	0	15	0	16	0	0	0	30	6	6	6	7
246	rrm	zf-CCCH	2	0	0	0	16	0	4	0	30	6	7	7	7
247	rrm	zf-CCHC	2	0	0	0	16	0	4	0	30	6	7	7	7
248	rrm	zf-RanBP	2	0	0	3	16	0	4	0	30	6	7	7	7
249	rvt	rve	2	0	2	7	16	0	7	17	30	6	7	7	7
250	zf-CCHC	rvt	2	0	0	2	16	0	0	7	30	6	7	7	7
251	SapB_2	SapB_1	2	0	0	0	16	0	0	0	30	6	6	6	7
252	Sec23_trunk	Sec23_helical	2	0	0	0	16	0	0	0	30	7	7	7	7
253	Sec23_helical	zf-Sec23_Sec24	2	0	0	0	16	0	0	0	30	7	7	7	7
254	Sec23_trunk	zf-Sec23_Sec24	2	0	0	0	16	0	0	0	30	7	7	7	7
255	SH3	UIM	2	0	0	0	16	0	0	0	30	6	7	7	7
256	SH3	VHS	2	0	0	0	16	0	0	0	30	6	7	7	7
257	Skp1	Skp1_POZ	100000	0	0	0	16	0	0	0	30	7	7	7	7
258	WD40	Sof1	100000	0	2	0	16	0	5	0	30	7	7	7	7
259	TFIIA_gamma	TFIIA_gamma_C	100000	0	0	0	16	0	0	0	30	7	7	7	7
260	WD40	TFIID_WDA	100000	0	2	0	16	0	5	0	30	7	7	7	7
261	ThiF	UBACT	100000	0	14	0	16	0	18	0	30	7	7	7	7
262	Topoisomer_I_N	Topoisomerase_I	100000	0	0	0	16	0	0	3	30	7	7	7	7
263	TPR	U-box	2	0	13	0	16	0	25	0	30	6	7	7	7
264	tRNA-synt_1c	tRNA_synt_1c_R1	2	0	15	0	16	0	30	0	30	6	7	6	7
265	tRNA-synt_1c	tRNA_synt_1c_R2	2	0	15	0	16	0	30	0	30	6	7	6	7
266	tRNA-synt_1c_C	tRNA_synt_1c_R1	2	0	15	0	16	0	7	0	30	6	7	6	7
267	tRNA-synt_1c_C	tRNA_synt_1c_R2	2	0	15	0	16	0	7	0	30	6	7	6	7
268	WHEP-TRS	tRNA-synt_2b	2	0	0	16	16	0	0	30	30	6	6	7	7
269	tRNA_synt_1c_R1	tRNA_synt_1c_R2	2	0	0	0	16	0	0	0	30	6	6	6	7
270	ubiquitin	UBA	2	0	0	14	16	0	0	30	30	7	7	7	7
271	ubiquitin	UCH	2	0	0	0	16	0	0	0	30	7	7	7	7
272	UCH	zf-UBP	3	0	0	1	16	0	0	1	30	7	7	7	7
273	UIM	VHS	2	0	0	0	16	0	0	0	30	6	7	7	7
274	WD40	Utp12	2	0	2	0	16	0	5	0	30	7	7	7	7
275	WD40	Utp21	100000	0	2	0	16	0	5	0	30	7	7	7	7
276	Vps16_C	Vps16_N	100000	0	0	0	16	0	0	0	30	7	7	7	7
277	WH2	WH1	2	0	0	0	16	0	0	0	30	6	6	6	7
278	zf-C3HC4	zf-CCCH	2	0	0	0	16	0	0	0	30	7	7	7	7
279	zf-C3HC4	zf-UBP	2	0	0	1	16	0	0	1	30	6	7	7	7
280	ZZ	zf-TAZ	2	0	0	0	16	0	0	0	30	6	7	6	7
# Specific missing-connections in organism: Archaea
1	AAA	Peptidase_M41	100000	0	16	0	16	30	30	30	30	7	7	7	7
2	CBS	DUF21	1	2	16	3	16	28	30	28	30	6	7	6	7
3	dsrm	Ribonuclease_3	100000	0	1	0	16	28	29	29	30	7	7	7	7
4	UBA	EF_TS	100000	0	14	0	16	30	30	30	30	6	7	6	7
5	formyl_transf	formyl_trans_C	100000	0	6	0	16	30	30	30	30	6	7	6	7
6	ketoacyl-synt	ketoacyl-synt_C	100000	0	0	0	16	25	25	25	30	7	7	7	7
7	PCRF	RF-1	100000	0	0	0	16	30	30	30	30	7	7	7	7
8	Peptidase_M16	Peptidase_M16_C	1	2	2	2	16	26	26	26	30	7	7	7	7
9	S4	Ribosomal_S4	1	2	16	2	16	30	30	30	30	7	7	7	7
10	S-AdoMet_synt	S-AdoMet_syntD2	100000	0	0	0	16	26	26	26	30	7	7	7	7
11	S-AdoMet_synt	S-AdoMet_syntD3	100000	0	0	0	16	26	26	26	30	7	7	7	7
12	S-AdoMet_syntD2	S-AdoMet_syntD3	100000	0	0	0	16	26	26	26	30	7	7	7	7
13	transket_pyr	transketolase	100000	0	10	9	16	28	29	28	30	7	7	7	7
14	transketolase_C	transketolase	100000	0	14	9	16	25	28	28	30	7	7	7	7
# Specific missing-connections in organism: Bacteria
1	AAA	cdc48_2	100000	15	16	15	16	0	30	0	30	6	7	6	7
2	AAA	cdc48_N	1	16	16	16	16	1	30	1	30	7	7	7	7
3	ABC_tran	fer4	2	16	16	16	16	0	30	25	30	7	7	7	7
4	ABC_tran	RLI	100000	16	16	16	16	0	30	0	30	7	7	7	7
5	Acetyltransf	Radical_SAM	6	15	16	16	16	0	27	28	30	7	7	7	7
6	cdc48_N	cdc48_2	100000	15	16	15	16	0	1	0	30	6	7	6	7
7	DNA_ligase	DNA_ligase_A_C	1	16	16	16	16	5	10	5	30	7	7	7	7
8	DNA_ligase	DNA_ligase_A_N	1	16	16	16	16	2	10	2	30	7	7	7	7
9	DNA_ligase_A_C	DNA_ligase_A_N	1	16	16	16	16	2	5	2	30	7	7	7	7
10	DNA_pol_B	DNA_pol_B_exo	1	16	16	16	16	3	3	3	30	7	7	7	7
11	KOW	eIF-5a	100000	14	16	14	16	0	30	0	30	7	7	7	7
12	eRF1_1	eRF1_2	100000	15	15	15	16	0	0	0	30	7	7	7	7
13	eRF1_1	eRF1_3	100000	15	15	15	16	0	0	0	30	7	7	7	7
14	eRF1_3	eRF1_2	100000	15	15	15	16	0	0	0	30	7	7	7	7
15	RLI	fer4	100000	16	16	16	16	0	0	25	30	7	7	7	7
16	TGS	GTP1_OBG	100000	15	16	16	16	0	27	30	30	7	7	7	7
17	KOW	Ribosomal_S4e	100000	13	16	16	16	0	30	0	30	6	7	6	7
18	PCNA	PCNA_C	100000	14	16	14	16	0	0	0	30	7	7	7	7
19	PUA	TruB_N	100000	15	16	16	16	0	16	28	30	7	7	7	7
20	RNA_POL_M_15KD	TFIIS	100000	14	15	15	16	0	0	0	30	6	6	7	7
21	RNA_pol_Rpb2_4	RNA_pol_Rpb2_5	100000	15	15	15	16	0	0	0	30	7	7	7	7
22	RNA_pol_Rpb2_6	RNA_pol_Rpb2_4	100000	15	15	15	16	0	30	0	30	7	7	7	7
23	RNA_pol_Rpb2_7	RNA_pol_Rpb2_4	100000	15	15	15	16	0	30	0	30	7	7	7	7
24	RNA_pol_Rpb2_6	RNA_pol_Rpb2_5	100000	15	15	15	16	0	30	0	30	7	7	7	7
25	RNA_pol_Rpb2_7	RNA_pol_Rpb2_5	100000	15	15	15	16	0	30	0	30	7	7	7	7
26	S1	RNA_pol_Rpb7_N	100000	16	16	16	16	0	30	0	30	6	7	7	7
27	XPG_N	XPG_I	100000	16	16	16	16	0	0	0	30	7	7	7	7
# Specific missing-connections in organism: Eukaryote
1	DHH	DHHA1	100000	16	16	16	16	28	28	30	30	0	5	7	7
2	PEP-utilizers	PEP-utilizers_C	1	16	16	16	16	26	28	26	30	1	2	1	7
3	Phage_integr_N	Phage_integrase	100000	13	13	14	16	25	25	28	30	0	0	0	7

Godzik Laboratory,
The Burnham Institute,
Contact: Yuzhen Ye