The unique domain combinations

Common combinations in all organisms

Connection	Domain1	Domain2	Effect	genomes	view graph
1	ATP-synt_ab_C	ATP-synt_ab	2	304	graph
2	ATP-synt_ab_C	ATP-synt_ab_N	2	304	graph
3	GATase	CTP_synth_N	100000	301	graph
4	GTP_EFTU_D2	EFG_IV	2	310	graph
5	GTP_EFTU_D2	EFG_C	2	310	graph
6	GTP_EFTU_D2	GTP_EFTU_D3	2	309	graph
7	GTP_EFTU_D2	GTP_EFTU	2	310	graph
8	Helicase_C	DEAD	2	307	graph
9	Helicase_C	ResIII	2	299	graph
10	Peptidase_M20	M20_dimer	2	286	graph
11	Pyr_redox	Pyr_redox_2	2	309	graph
12	Pyr_redox	Pyr_redox_dim	2	297	graph
13	RNA_pol_Rpb2_7	RNA_pol_Rpb2_6	2	309	graph
14	SRP54	SRP_SPB	2	303	graph
15	SRP54	SRP54_N	2	303	graph
16	Hydrolase	E1-E2_ATPase	2	281	graph
17	ATP-synt_ab	ATP-synt_ab_N	2	308	graph
18	Enolase_C	Enolase_N	100000	303	graph
19	OTCace	OTCace_N	2	281	graph
20	PGM_PMM_I	PGM_PMM_II	2	295	graph
21	PGM_PMM_I	PGM_PMM_III	2	291	graph
22	PGM_PMM_I	PGM_PMM_IV	2	285	graph
23	PGM_PMM_II	PGM_PMM_III	2	289	graph
24	Ribonuc_red_lgC	Ribonuc_red_lgN	2	259	graph
25	Ribosomal_L11	Ribosomal_L11_N	100000	307	graph
26	Ribosomal_S5	Ribosomal_S5_C	100000	308	graph
27	RNA_pol_Rpb2_2	RNA_pol_Rpb2_1	2	305	graph
28	RNA_pol_Rpb2_1	RNA_pol_Rpb2_3	2	309	graph
29	RNA_pol_Rpb2_2	RNA_pol_Rpb2_3	2	305	graph
30	tRNA-synt_2b	Seryl_tRNA_N	100000	305	graph
31	Topoisom_bac	Toprim	2	302	graph
32	tRNA-synt_1d	tRNA-synt_1d_C	2	308	graph
33	tRNA-synt_2	tRNA_anti	2	309	graph
34	tRNA_SAD	tRNA-synt_2c	2	308	graph
35	2-Hacid_dh	2-Hacid_dh_C	2	255	graph
36	SRP54_N	SRP_SPB	2	302	graph
37	Ribosomal_L2_C	Ribosomal_L2	100000	306	graph
38	RNA_pol_L	RNA_pol_A_bac	2	307	graph
39	Gln-synt_C	Gln-synt_N	100000	258	graph
40	Pyr_redox_2	Pyr_redox_dim	2	297	graph
41	EFG_C	EFG_IV	2	310	graph
42	GTP_EFTU	EFG_IV	2	310	graph
43	GTP_EFTU	EFG_C	2	310	graph
44	GTP_EFTU_D3	GTP_EFTU	2	309	graph
45	HGTP_anticodon	tRNA-synt_2b	2	310	graph
46	Anticodon_1	tRNA-synt_1	2	309	graph
47	Gp_dh_N	Gp_dh_C	2	302	graph
48	Ribosomal_L5	Ribosomal_L5_C	100000	310	graph
49	Ribosomal_S3_C	KH_2	2	308	graph
50	RNA_pol_Rpb1_2	RNA_pol_Rpb1_3	2	309	graph
51	RNA_pol_Rpb1_1	RNA_pol_Rpb1_2	2	309	graph
52	RNA_pol_Rpb1_4	RNA_pol_Rpb1_2	2	292	graph
53	RNA_pol_Rpb1_2	RNA_pol_Rpb1_5	2	292	graph
54	RNA_pol_Rpb1_1	RNA_pol_Rpb1_3	2	309	graph
55	RNA_pol_Rpb1_4	RNA_pol_Rpb1_3	2	308	graph
56	RNA_pol_Rpb1_3	RNA_pol_Rpb1_5	2	308	graph
57	RNA_pol_Rpb1_1	RNA_pol_Rpb1_4	2	292	graph
58	RNA_pol_Rpb1_1	RNA_pol_Rpb1_5	2	292	graph
59	TPP_enzyme_N	TPP_enzyme_C	2	253	graph
60	GHMP_kinases_N	GHMP_kinases_C	2	269	graph
61	RNA_pol_Rpb1_4	RNA_pol_Rpb1_5	2	308	graph

Unique(missing) domain combinations in the three kindoms

cf: the frequency of the combinations in the genomes; d1: the frequency of component domain 1 in the genomes; d2: the frequency of component domain 2 in the genomes; gn: the number of sampled genomes in each kindom; the specific combinations of common domains are highlighted in green cells, while the specific combinations of a common domain with other domains are highlighted in yellow cells.

Connection	Domain1	Domain2	Effect	Archaea				Bacteria				Eukaryote
Connection	Domain1	Domain2	Effect	cf	f1	f2	gn	cf	f1	f2	gn	cf	f1	f2	gn
# Unique combinations in Archaea
1	GatB	GAD	2	21	23	22	24	0	204	244	259	0	19	5	28
2	GatB_N	GAD	2	21	24	22	24	0	205	244	259	0	22	5	28
3	GatB_Yqey	GAD	2	20	21	22	24	0	226	244	259	0	17	5	28
4	DUF650	DUF651	100000	22	22	22	24	0	0	0	259	0	0	0	28
5	PyrI	PyrI_C	100000	23	23	23	24	35	38	39	259	0	0	1	28
6	TGS	MMR_HSR1_C	2	24	24	24	24	0	235	0	259	0	26	9	28
# Unique combinations in Bacteria
1	Ala_racemase_C	Ala_racemase_N	2	1	1	4	24	216	218	227	259	2	2	20	28
2	DNA_pol3_alpha	PHP	2	0	0	19	24	259	259	259	259	0	0	12	28
3	DNA_pol3_alpha	tRNA_anti	2	0	0	24	24	226	259	259	259	0	0	26	28
4	DnaB	DnaB_C	100000	0	0	1	24	256	256	259	259	0	0	0	28
5	Glyco_transf_28	Glyco_tran_28_C	100000	4	4	9	24	239	240	239	259	2	10	23	28
6	Helicase_C	TRCF	2	0	24	0	24	225	259	225	259	0	28	0	28
7	Helicase_C	CarD_TRCF	2	0	24	0	24	237	259	239	259	1	28	1	28
8	IF3_N	IF3_C	100000	0	0	0	24	255	255	255	259	2	3	4	28
9	PHP	tRNA_anti	2	0	19	24	24	226	259	259	259	0	12	26	28
10	RNase_PH	S1	2	0	19	24	24	240	242	255	259	4	26	27	28
11	RNase_PH_C	S1	2	0	19	24	24	240	242	255	259	5	21	27	28
12	S4	PseudoU_synth_2	2	0	24	1	24	247	259	250	259	4	28	25	28
13	Transpeptidase	PBP_dimer	2	0	0	0	24	238	239	238	259	0	0	0	28
14	Transpeptidase	Transgly	2	0	0	0	24	223	239	223	259	0	0	0	28
15	tRNA-synt_2d	Phe_tRNA-synt_N	100000	0	24	0	24	238	259	238	259	0	27	0	28
16	tRNA_bind	B3_4	2	0	24	13	24	242	259	245	259	0	26	25	28
17	tRNA_bind	B5	2	0	24	23	24	248	259	255	259	0	26	26	28
18	tRNA_bind	FDX-ACB	2	0	24	1	24	241	259	243	259	0	26	22	28
19	Bac_DnaA	Bac_DnaA_C	100000	0	0	0	24	254	255	254	259	0	1	0	28
20	AAA	RuvB_C	2	0	24	0	24	246	259	247	259	0	28	0	28
21	AAA	RuvB_N	2	0	24	0	24	245	259	245	259	1	28	1	28
22	FDX-ACB	B3_4	2	0	1	13	24	237	243	245	259	0	22	25	28
23	FDX-ACB	B5	2	0	1	23	24	242	243	255	259	0	22	26	28
24	DNA_ligase_ZBD	BRCT	2	2	2	2	24	229	231	251	259	0	1	26	28
25	DNA_ligase_ZBD	DNA_ligase_aden	2	2	2	2	24	231	231	257	259	1	1	3	28
26	DNA_ligase_ZBD	DNA_ligase_OB	2	2	2	2	24	231	231	255	259	1	1	2	28
27	DNA_pol3_beta	DNA_pol3_beta_2	2	0	0	0	24	252	257	254	259	1	1	1	28
28	DNA_pol3_beta	DNA_pol3_beta_3	2	0	0	0	24	254	257	256	259	1	1	1	28
29	DNA_pol3_beta_3	DNA_pol3_beta_2	2	0	0	0	24	251	256	254	259	1	1	1	28
30	ATP-synt_ab	Rho_RNA_bind	2	0	24	0	24	208	258	208	259	1	26	1	28
31	EFP	EFP_N	100000	0	0	0	24	259	259	259	259	1	2	2	28
32	tRNA_anti	Exonuc_VII_L	100000	2	24	2	24	216	259	223	259	0	26	0	28
33	tRNA-synt_2	GAD	2	0	24	22	24	244	259	244	259	5	26	5	28
34	tRNA_anti	GAD	2	0	24	22	24	242	259	244	259	4	26	5	28
35	GreA_GreB	GreA_GreB_N	100000	0	0	0	24	234	234	242	259	0	0	0	28
36	DEAD	TRCF	2	0	24	0	24	225	255	225	259	0	28	0	28
37	DEAD	CarD_TRCF	2	0	24	0	24	237	255	239	259	1	28	1	28
38	RelA_SpoT	TGS	2	0	0	24	24	219	227	235	259	2	4	26	28
39	RelA_SpoT	HD	2	0	0	24	24	222	227	249	259	2	4	24	28
40	Mur_ligase	Mur_ligase_C	2	0	0	8	24	239	239	245	259	2	2	10	28
41	Mur_ligase	Mur_ligase_M	2	0	0	13	24	239	239	248	259	2	2	16	28
42	MurB_C	FAD_binding_4	100000	1	1	15	24	232	239	240	259	0	0	23	28
43	Ribosomal_L9_C	Ribosomal_L9_N	100000	0	0	0	24	242	242	258	259	1	1	15	28
44	RNA_pol_A_CTD	RNA_pol_L	2	0	0	24	24	258	258	259	259	1	1	26	28
45	RNA_pol_A_CTD	RNA_pol_A_bac	2	0	0	23	24	258	258	259	259	1	1	26	28
46	S1	PNPase	2	0	24	0	24	240	255	242	259	3	27	8	28
47	KH_1	S1	2	1	24	24	24	242	255	255	259	5	27	27	28
48	Sigma70_r1_2	Sigma70_r3	2	0	0	0	24	250	251	257	259	2	2	3	28
49	Sigma70_r1_2	Sigma70_r4	2	0	0	3	24	248	251	257	259	2	2	3	28
50	Sigma70_r1_2	Sigma70_r2	2	0	0	0	24	251	251	259	259	2	2	3	28
51	Toprim	zf-CHC2	2	0	24	0	24	257	259	258	259	0	25	1	28
52	Toprim	Toprim_N	2	0	24	0	24	257	259	258	259	0	25	3	28
53	CarD_TRCF	TRCF	2	0	0	0	24	224	239	225	259	0	1	0	28
54	zf-CHC2	Toprim_N	2	0	0	0	24	258	258	258	259	1	1	3	28
55	RimM	PRC	100000	0	0	17	24	217	221	226	259	1	3	1	28
56	ACT	HD	2	0	24	24	24	208	226	249	259	0	22	24	28
57	DNA_pol_A	5_3_exonuc_N	2	0	0	0	24	239	240	259	259	1	25	4	28
58	DNA_pol_A	5_3_exonuc	2	0	0	2	24	239	240	259	259	1	25	12	28
59	Radical_SAM	HemN_C	100000	0	24	0	24	228	247	228	259	5	27	5	28
60	BRCT	DNA_ligase_aden	2	2	2	2	24	250	251	257	259	1	26	3	28
61	BRCT	DNA_ligase_OB	2	2	2	2	24	250	251	255	259	1	26	2	28
62	TGS	HD	2	0	24	24	24	219	235	249	259	2	26	24	28
63	5_3_exonuc	5_3_exonuc_N	2	0	2	0	24	259	259	259	259	4	12	4	28
64	AAA_2	zf-C4_ClpX	100000	0	2	0	24	241	256	241	259	0	26	1	28
65	Ribosomal_S3_C	Ribosomal_S3_N	2	0	24	0	24	259	259	259	259	2	26	2	28
66	Ribosomal_S3_N	KH_2	2	0	0	24	24	259	259	259	259	1	2	25	28
67	RuvB_C	RuvB_N	2	0	0	0	24	242	247	245	259	0	0	1	28
68	Sigma70_r3	Sigma70_r4	2	0	0	3	24	255	257	257	259	3	3	3	28
69	Sigma70_r3	Sigma70_r2	2	0	0	0	24	257	257	259	259	3	3	3	28
70	FKBP_C	Trigger_C	2	0	21	0	24	223	255	248	259	1	26	1	28
71	Trigger_N	Trigger_C	2	0	0	0	24	248	256	248	259	1	1	1	28
72	DNA_ligase_OB	DNA_ligase_aden	2	2	2	2	24	255	255	257	259	2	2	3	28
73	Sigma70_r2	Sigma70_r4	2	0	0	3	24	257	259	257	259	3	3	3	28
74	FKBP_C	Trigger_N	2	0	21	0	24	226	255	256	259	1	26	1	28
75	SecA_PP_bind	SecA_SW	2	0	0	0	24	259	259	259	259	1	1	1	28
76	SecA_PP_bind	SecA_DEAD	2	0	0	0	24	259	259	259	259	1	1	4	28
77	Response_reg	Trans_reg_C	2	0	12	0	24	228	240	240	259	1	18	1	28
78	Dala_Dala_lig_C	Dala_Dala_lig_N	2	0	2	0	24	240	241	240	259	0	0	1	28
79	SecA_DEAD	SecA_SW	2	0	0	0	24	259	259	259	259	1	4	1	28
80	MMR_HSR1	KH_2	3	0	24	24	24	240	259	259	259	1	27	25	28
81	FAD_syn	Flavokinase	2	0	0	0	24	242	251	244	259	0	2	22	28
82	ACP_syn_III_C	ACP_syn_III	4	1	20	2	24	226	226	226	259	2	2	2	28
# Unique combinations in Eukaryote
1	Ank	zf-DHHC	2	0	5	0	24	0	125	0	259	24	27	28	28
2	Biotin_carb_C	Carboxyl_trans	2	0	13	11	24	10	233	231	259	24	25	25	28
3	CH	EB1	2	0	0	0	24	0	0	0	259	25	27	25	28
4	CPSase_L_D3	CPSase_sm_chain	2	0	19	19	24	0	224	224	259	24	25	25	28
5	CPSase_L_D3	GATase	2	0	19	23	24	0	224	255	259	24	25	26	28
6	CPSase_L_chain	CPSase_sm_chain	2	0	19	19	24	0	242	224	259	24	25	25	28
7	CPSase_L_D2	CPSase_sm_chain	2	0	19	19	24	0	242	224	259	24	25	25	28
8	Dynamin_M	Dynamin_N	2	0	0	0	24	0	0	39	259	26	26	26	28
9	Dynamin_M	GED	2	0	0	0	24	0	0	0	259	26	26	26	28
10	GATase	MGS	2	0	23	12	24	0	255	230	259	23	26	25	28
11	CPSase_L_chain	GATase	2	0	19	23	24	0	242	255	259	24	25	26	28
12	CPSase_L_D2	GATase	2	0	19	23	24	0	242	255	259	24	25	26	28
13	Helicase_C	Sec63	2	0	24	0	24	0	259	0	259	23	28	24	28
14	Helicase_C	Chromo	2	0	24	0	24	0	259	0	259	23	28	26	28
15	Helicase_C	DSHCT	2	0	24	0	24	31	259	31	259	26	28	26	28
16	Ku_N	Ku	2	0	0	1	24	0	0	49	259	23	23	23	28
17	MA3	MIF4G	2	0	0	0	24	0	0	0	259	25	25	26	28
18	PAP_central	PAP_RNA-bind	2	0	0	0	24	0	0	0	259	26	26	26	28
19	Pkinase	PH	2	0	8	0	24	0	162	0	259	24	28	27	28
20	PSP	DUF382	2	0	0	0	24	0	0	0	259	23	25	23	28
21	RNA_pol_Rpb1_6	RNA_pol_Rpb1_7	2	0	0	0	24	0	0	0	259	23	24	23	28
22	RNA_pol_Rpb1_6	RNA_pol_Rpb1_2	2	0	0	24	24	0	0	258	259	24	24	27	28
23	RNA_pol_Rpb1_6	RNA_pol_Rpb1_3	2	0	0	24	24	0	0	258	259	24	24	27	28
24	RNA_pol_Rpb1_6	RNA_pol_Rpb1_1	2	0	0	24	24	0	0	258	259	24	24	27	28
25	RNA_pol_Rpb1_6	RNA_pol_Rpb1_4	2	0	0	24	24	0	0	258	259	24	24	26	28
26	RNA_pol_Rpb1_6	RNA_pol_Rpb1_5	2	0	0	24	24	0	0	258	259	24	24	26	28
27	DEAD	Sec63	2	0	24	0	24	0	255	0	259	23	28	24	28
28	Skp1	Skp1_POZ	100000	0	0	0	24	0	0	0	259	25	26	25	28
29	WW	FF	2	0	0	0	24	0	0	2	259	23	26	24	28
30	zf-C3HC4	zf-CCCH	2	0	0	0	24	0	1	0	259	23	28	26	28
31	zf-Sec23_Sec24	Gelsolin	2	0	0	0	24	0	0	0	259	25	25	26	28
32	zf-Sec23_Sec24	Sec23_trunk	2	0	0	0	24	0	0	0	259	25	25	25	28
33	zf-Sec23_Sec24	Sec23_BS	2	0	0	0	24	0	0	0	259	25	25	25	28
34	zf-Sec23_Sec24	Sec23_helical	2	0	0	0	24	0	0	0	259	25	25	25	28
35	zf-UBP	UCH	2	0	2	0	24	0	4	4	259	26	26	27	28
36	zf-UBP	UBA	2	0	2	20	24	0	4	259	259	23	26	27	28
37	6PF2K	PGAM	2	0	0	14	24	2	2	231	259	23	23	25	28
38	ABC_tran	ABC2_membrane	2	0	24	23	24	46	259	219	259	25	28	25	28
39	AAA	RFC1	2	0	24	0	24	0	259	0	259	25	28	25	28
40	AAA	MIT	3	3	24	3	24	0	259	0	259	23	28	24	28
41	Alpha_adaptinC2	Adaptin_N	2	0	0	1	24	0	0	0	259	24	24	27	28
42	Coatomer_WDAD	COPI_C	2	0	0	0	24	0	0	0	259	25	25	25	28
43	WD40	Coatomer_WDAD	2	0	3	0	24	0	50	0	259	25	28	25	28
44	CPSase_L_chain	Carboxyl_trans	2	0	19	11	24	10	242	231	259	24	25	25	28
45	CRAL_TRIO	CRAL_TRIO_N	2	0	0	0	24	0	1	0	259	24	26	24	28
46	Cyclin_C	Cyclin_N	2	0	0	0	24	0	0	0	259	25	25	27	28
47	DNA_gyraseB	DNA_topoisoIV	2	0	10	10	24	0	259	259	259	26	27	27	28
48	HATPase_c	DNA_topoisoIV	2	0	24	10	24	0	259	259	259	26	27	27	28
49	GED	Dynamin_N	2	0	0	0	24	0	0	39	259	26	26	26	28
50	GSH_synthase	GSH_synth_ATP	100000	0	0	0	24	1	1	1	259	24	24	24	28
51	DEAD	DSHCT	2	0	24	0	24	31	255	31	259	26	28	26	28
52	mRNA_cap_C	mRNA_cap_enzyme	2	0	0	0	24	0	0	0	259	25	25	25	28
53	IQ	Myosin_head	2	0	0	0	24	0	2	0	259	25	26	26	28
54	Myosin_head	Myosin_N	2	0	0	0	24	0	0	1	259	25	26	25	28
55	NMT	NMT_C	100000	0	0	0	24	0	0	0	259	25	26	25	28
56	PI-PLC-X	PI-PLC-Y	2	0	0	0	24	0	16	0	259	24	24	24	28
57	PI3_PI4_kinase	PI3Ka	2	0	0	0	24	0	9	0	259	25	28	25	28
58	Rad21_Rec8_N	Rad21_Rec8	100000	0	0	0	24	0	0	0	259	23	23	23	28
59	Ribosomal_L23eN	Ribosomal_L23	100000	0	0	24	24	0	0	257	259	23	23	27	28
60	Ribosomal_L30	Ribosomal_L30_N	100000	0	24	0	24	0	195	0	259	25	27	25	28
61	RNA_pol_Rpb1_2	RNA_pol_Rpb1_7	2	0	24	0	24	0	258	0	259	23	27	23	28
62	RNA_pol_Rpb1_3	RNA_pol_Rpb1_7	2	0	24	0	24	0	258	0	259	23	27	23	28
63	RNA_pol_Rpb1_1	RNA_pol_Rpb1_7	2	0	24	0	24	0	258	0	259	23	27	23	28
64	RNA_pol_Rpb1_4	RNA_pol_Rpb1_7	2	0	24	0	24	0	258	0	259	23	26	23	28
65	RNA_pol_Rpb1_5	RNA_pol_Rpb1_7	2	0	24	0	24	0	258	0	259	23	26	23	28
66	ThiF	UBACT	2	0	24	0	24	0	196	0	259	26	27	26	28
67	Clathrin	Clathrin_propel	100000	0	0	0	24	0	0	0	259	24	25	24	28
68	SNARE	Syntaxin	100000	0	0	1	24	0	0	4	259	24	25	24	28
69	DUF663	AARP2CN	2	0	0	0	24	0	0	0	259	23	25	24	28
70	TPR_1	PPP5	2	0	20	0	24	0	213	0	259	23	27	24	28
71	Gelsolin	Sec23_trunk	2	0	0	0	24	0	0	0	259	25	26	25	28
72	Gelsolin	Sec23_BS	2	0	0	0	24	0	0	0	259	25	26	25	28
73	Sec23_helical	Gelsolin	2	0	0	0	24	0	0	0	259	25	25	26	28
74	WD40	F-box	2	0	3	0	24	1	50	9	259	23	28	25	28
75	Adaptin_N	DUF1606	100000	0	1	0	24	0	0	0	259	26	27	26	28
76	SGS	CS	2	0	0	2	24	0	0	0	259	25	26	26	28
77	WD40	Sof1	100000	0	3	0	24	0	50	0	259	24	28	24	28
78	UBA	UCH	2	0	20	0	24	0	259	4	259	23	27	27	28
79	Vps16_C	Vps16_N	100000	0	0	0	24	0	0	0	259	23	23	23	28
80	FtsJ	Spb1_C	100000	0	14	0	24	0	217	0	259	25	27	25	28
81	Nop	NOP5NT	2	0	24	0	24	0	0	0	259	27	27	27	28
82	PCI	eIF-3c_N	2	0	0	0	24	0	0	0	259	23	26	24	28
83	PCI	Rpn3_C	2	0	0	0	24	0	0	0	259	25	26	25	28
84	HEAT	IBN_N	2	0	10	0	24	0	46	0	259	24	27	27	28
85	Metallophos	Mre11_DNA_bind	100000	0	24	0	24	0	253	0	259	26	28	26	28
86	UBX	SEP	100000	0	0	0	24	0	0	0	259	24	26	24	28
87	RRM_1	PABP	2	0	0	0	24	0	54	0	259	25	28	25	28
88	Glycos_transf_1	PIGA	2	0	24	0	24	0	236	0	259	25	26	25	28
89	CPSase_L_D2	Carboxyl_trans	2	0	19	11	24	10	242	231	259	24	25	25	28
90	Biotin_lipoyl	Carboxyl_trans	2	0	22	11	24	10	254	231	259	24	25	25	28
91	RNA_pol_Rpb5_C	RNA_pol_Rpb5_N	100000	0	24	0	24	0	0	0	259	23	25	24	28
92	TFIIS_C	TFIIS_M	2	0	23	0	24	0	0	0	259	26	26	26	28
93	TFIIB	BRF1	2	0	24	0	24	0	0	0	259	23	26	23	28
94	FATC	PI3_PI4_kinase	2	0	0	0	24	0	0	9	259	24	24	28	28
95	PPP5	Metallophos	2	0	0	24	24	0	0	253	259	23	24	28	28
96	IQ	Myosin_N	2	0	0	0	24	0	2	1	259	23	26	25	28
97	AAA_5	DHC_N2	2	0	24	0	24	0	148	0	259	25	26	25	28
98	Ribosomal_L10	Ribosomal_60s	100000	4	24	24	24	0	259	3	259	25	27	27	28
99	Sec23_trunk	Sec23_BS	2	0	0	0	24	0	0	0	259	25	25	25	28
100	Sec23_helical	Sec23_trunk	2	0	0	0	24	0	0	0	259	25	25	25	28
101	DUF1227	DEAD_2	100000	0	0	18	24	0	0	17	259	24	24	26	28
102	NOG1	NOGCT	100000	0	15	0	24	0	0	0	259	26	26	26	28
103	WD40	COPI_C	2	0	3	0	24	0	50	0	259	24	28	25	28
104	Sec23_helical	Sec23_BS	2	0	0	0	24	0	0	0	259	25	25	25	28
105	Topoisom_I	Topoisom_I_N	100000	0	0	0	24	0	1	0	259	25	25	25	28
106	Lipin_N	LNS2	100000	0	0	0	24	0	0	1	259	25	26	25	28
107	UBA	ubiquitin	2	0	20	0	24	0	259	1	259	26	27	27	28
108	Bromodomain	Acetyltransf_1	2	0	0	24	24	0	0	243	259	23	26	28	28
109	Hexokinase_2	Hexokinase_1	2	0	0	0	24	4	5	4	259	24	24	25	28
110	GST_C	EF1G	2	0	3	0	24	0	135	0	259	24	25	25	28
111	SNF2_N	Chromo	2	0	11	0	24	0	173	0	259	23	26	26	28
112	HMG_CoA_synt_N	HMG_CoA_synt_C	100000	3	17	3	24	48	48	48	259	23	24	23	28
113	Kelch_1	Kelch_2	2	1	5	1	24	5	44	9	259	27	27	27	28
114	NOSIC	NOP5NT	2	0	17	0	24	0	0	0	259	27	27	27	28
115	PROCN	PRO8NT	2	0	0	0	24	0	0	0	259	24	25	24	28
116	WD40	BING4CT	100000	0	3	0	24	0	50	0	259	25	28	25	28
117	MMR_HSR1	NGP1NT	100000	0	24	0	24	0	259	0	259	23	27	24	28
118	WD40	NLE	100000	0	3	0	24	0	50	0	259	24	28	24	28
119	IBN_N	Xpo1	2	0	0	0	24	0	0	0	259	26	27	26	28
120	WD40	LisH	2	0	3	0	24	0	50	0	259	24	28	27	28
121	zf-C3HC4	Pex2_Pex12	2	0	0	0	24	0	1	0	259	23	28	24	28
122	Pkinase	Pkinase_C	2	0	8	0	24	0	162	0	259	26	28	26	28
123	tRNA_anti	Rep_fac-A_C	2	4	24	4	24	0	259	0	259	25	26	25	28
# Specific missing-combinations in organism: Archaea
1	GATase	GMP_synt_C	1	2	23	23	24	235	255	235	259	24	26	24	28
2	GTP1_OBG	MMR_HSR1	100000	0	0	24	24	259	259	259	259	24	24	27	28
3	S4	Ribosomal_S4	1	4	24	4	24	256	259	256	259	26	28	26	28
4	AAA	Peptidase_M41	100000	0	24	0	24	258	259	258	259	24	28	24	28
5	AAA	FtsH_ext	100000	0	24	0	24	253	259	253	259	23	28	23	28
6	Peptidase_M16	Peptidase_M16_C	1	2	2	3	24	222	223	223	259	27	27	27	28
7	ketoacyl-synt	Ketoacyl-synt_C	100000	0	10	0	24	240	240	240	259	25	25	25	28
8	Peptidase_M41	FtsH_ext	100000	0	0	0	24	253	258	253	259	23	24	23	28
9	Transket_pyr	Transketolase_N	100000	0	16	13	24	241	257	249	259	25	27	25	28
10	MMR_HSR1	DUF933	100000	0	24	0	24	256	259	259	259	25	27	25	28
11	S-AdoMet_synt_M	S-AdoMet_synt_C	100000	0	0	0	24	245	246	247	259	24	24	24	28
12	S-AdoMet_synt_M	S-AdoMet_synt_N	100000	0	0	0	24	246	246	247	259	24	24	24	28
13	S-AdoMet_synt_N	S-AdoMet_synt_C	100000	0	0	0	24	245	247	247	259	24	24	24	28
14	NAD_Gly3P_dh_N	NAD_Gly3P_dh_C	1	2	2	2	24	240	240	240	259	24	24	24	28
# Specific missing-combinations in organism: Bacteria
1	DNA_pol_B	DNA_pol_B_exo	1	24	24	24	24	40	40	42	259	26	26	26	28
2	RNA_pol_Rpb2_5	RNA_pol_Rpb2_6	100000	24	24	24	24	0	0	258	259	26	26	27	28
3	RNA_pol_Rpb2_5	RNA_pol_Rpb2_7	100000	24	24	24	24	0	0	258	259	26	26	27	28
4	RNA_pol_Rpb2_5	RNA_pol_Rpb2_4	100000	24	24	24	24	0	0	0	259	25	26	25	28
5	RNA_pol_Rpb2_6	RNA_pol_Rpb2_4	100000	24	24	24	24	0	258	0	259	25	27	25	28
6	ABC_tran	Fer4	2	24	24	24	24	0	259	231	259	26	28	27	28
7	ABC_tran	RLI	100000	24	24	24	24	0	259	0	259	26	28	26	28
8	AAA	CDC48_N	1	24	24	24	24	6	259	6	259	26	28	26	28
9	AAA	Rep_fac_C	1	22	24	24	24	1	259	1	259	26	28	26	28
10	Ribosomal_S15	Ribosomal_S13_N	100000	24	24	24	24	0	258	0	259	27	28	27	28
11	S1	EIF_2_alpha	100000	23	24	24	24	0	255	0	259	26	27	26	28
12	XPG_I	XPG_N	100000	24	24	24	24	0	0	0	259	26	26	26	28
13	DNA_ligase_A_N	DNA_ligase_A_M	1	24	24	24	24	8	8	80	259	26	26	27	28
14	DNA_ligase_A_N	DNA_ligase_A_C	1	24	24	24	24	8	8	41	259	26	26	26	28
15	DNA_ligase_A_M	DNA_ligase_A_C	1	24	24	24	24	41	80	41	259	26	27	26	28
16	Fer4	RLI	100000	24	24	24	24	0	231	0	259	26	27	26	28
17	Acetyltransf_1	Radical_SAM	1	22	24	24	24	2	243	247	259	24	28	27	28
18	eRF1_1	eRF1_2	100000	24	24	24	24	0	0	0	259	27	27	27	28
19	eRF1_1	eRF1_3	100000	24	24	24	24	0	0	2	259	27	27	27	28
20	eRF1_2	eRF1_3	100000	24	24	24	24	0	0	2	259	27	27	27	28
21	MMR_HSR1	TGS	4	24	24	24	24	0	259	235	259	26	27	26	28
22	PCNA_C	PCNA_N	100000	21	21	24	24	0	0	0	259	27	27	27	28
23	PUA	TruB_N	1	24	24	24	24	1	160	246	259	26	27	26	28
24	PUA	DKCLD	2	20	24	23	24	0	160	3	259	25	27	25	28
25	RS4NT	Ribosomal_S4e	100000	21	21	24	24	0	0	0	259	27	27	27	28
26	TFIIB	TFIIB_Zn_Ribbon	100000	23	24	24	24	0	0	3	259	25	26	26	28
27	RNA_pol_Rpb2_7	RNA_pol_Rpb2_4	100000	24	24	24	24	0	258	0	259	25	27	25	28
28	TruB_N	DKCLD	1	20	24	23	24	3	246	3	259	25	26	25	28
# Specific missing-combinations in organism: Eukaryote
1	PEP-utilizers	PEP-utilizers_C	1	23	23	23	24	237	243	237	259	3	5	3	28
2	DHHA1	DHH	100000	22	23	23	24	242	259	242	259	0	21	10	28

Godzik Laboratory,
The Burnham Institute,
Contact: yye@burnham.org